Brain atrophy in frontotemporal dementia.

Patterns of brain atrophy in frontotemporal dementia and semantic dementia.

OBJECTIVE To identify and compare the patterns of cerebral atrophy associated with two clinical variants of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (FTD) and semantic dementia (SemD). METHODS Twenty patients with FTLD were classified as having FTD (N = 8) or SemD (N = 12) based on current clinical criteria. Both groups showed a similar spectrum of behavioral abnormal...

Dyslexia susceptibility genes influence brain atrophy in frontotemporal dementia

OBJECTIVE In this study, we evaluated whether variations within genes specifically associated with dyslexia, namely KIAA0319, DCDC2, and CNTNAP2, were associated with greater damage of language-related regions in patients with frontotemporal dementia (FTD) and primary progressive aphasia (PPA) in particular. METHODS A total of 118 patients with FTD, 84 with the behavioral variant of FTD (bvFT...

Deformation-based morphometry reveals brain atrophy in frontotemporal dementia.

OBJECTIVE To compare deformation-based maps of local anatomical size between subjects with frontotemporal dementia (FTD) and healthy subjects to identify regions of the brain involved in FTD. DESIGN Structural magnetic resonance images were obtained from 22 subjects with FTD and 22 cognitively normal, age-matched controls. We applied deformation-based morphometry and compared anatomy between ...

Assessment of Aphasia in Iranian Patients Suffering From Frontotemporal Dementia

Objective Frontotemporal dementia (FTD) is an uncommon type of dementia. The hallmark feature of FTD is the presentation with aphasia, or behavioral changes which are varies in different subtypes of the disease. We propose a quantitative aphasia test as an additive diagnostic tool for differentiation of FTD subtypes. Method: The study was performed on 20 patients, who were referred to dementia...

Thalamic atrophy in frontotemporal dementia — Not just a C9orf72 problem